Quality CLEEN

Cleaning Validation Audit Portal

Stop scrambling through paper binders when the inspector arrives. The CLEEN Audit Portal stores every cleaning event, analytical result, and equipment release in a searchable database with 21 CFR Part 11 audit trails — so any record is retrievable in seconds, not hours.

Key Highlights

01 Any cleaning record retrieved in seconds
02 21 CFR Part 11 compliant audit trails
03 One-click inspector-ready reports
04 Real-time equipment status across sites

Regulatory Context

What FDA Inspectors Cite

21 CFR 211.67 Documentation Failure
1 / 5

Cleaning validation records could not be produced during inspection

The firm was unable to produce cleaning validation records on request. Documentation was stored across disconnected systems and paper files. Retrieval took over four hours and key documents were missing entirely.

Fareva Amboise · 2025-09-16
21 CFR 211.67 Traceability Gap
2 / 5

No traceability between cleaning procedures and analytical results

Cleaning validation documentation did not link procedures performed to test results or equipment release decisions. The firm could not reconstruct cleaning history for specific equipment during the inspection period.

Otsuka Pharmaceutical Co., Ltd. · 2024-03-22
21 CFR 211.68 Data Integrity
3 / 5

Spreadsheet-based records lacked audit trails and version control

Cleaning validation calculations were maintained in spreadsheets without access controls or electronic signatures. Multiple versions existed with different results. The firm could not determine which was the approved calculation.

F.H. Investments Inc. · 2024-11-08
21 CFR 211.67 Incomplete Records
4 / 5

Incomplete documentation of cleaning events between product campaigns

Cleaning records for shared equipment were incomplete. Some changeovers were documented, others were not. No centralised system ensured every cleaning event was recorded.

Alembic Pharmaceuticals Limited (Units I and II) · 2025-05-31
21 CFR 211.192 Deviation Traceability
5 / 5

OOS cleaning results could not be linked to corrective actions

When cleaning failed acceptance criteria, no traceable link existed between the OOS result, investigation, CAPA, re-cleaning, and verification. Deviation-to-CAPA documentation was scattered across multiple systems.

Jiangsu Hengrui Pharmaceuticals Co., Ltd · 2024-01-16

The Problem

Why Cleaning Audits Fail

Challenge 1 1 / 5

Scattered Records

  • 200 equipment × 5 years = tens of thousands of paper documents
  • Finding a specific record from 18 months ago takes hours
  • Inspectors interpret slow retrieval as evidence of inadequate control
Challenge 2 2 / 5

No Compliant Audit Trail

  • Excel files emailed between QA and production with no access controls
  • No electronic signature trail for limit calculations or equipment release
  • Cannot demonstrate complete record history during inspections
Challenge 3 3 / 5

Manual Report Assembly

  • Report assembly from paper, spreadsheets, and LIMS takes days
  • Quality depends on which analyst is available during the inspection
  • Trend analysis is impossible without structured, queryable data
Challenge 4 4 / 5

Unknown Equipment Status

  • No real-time view of clean/dirty/in-process/on-hold across the facility
  • Paper-based status boards are updated manually, often after the fact
  • Multi-site companies cannot demonstrate consistent tracking
Challenge 5 5 / 5

Broken Deviation Chains

  • Deviations in QMS, re-cleaning on paper, verification in LIMS
  • No single view of a cleaning failure from OOS to resolution
  • Broken chains signal systemic quality problems to inspectors

Audit Readiness in Leucine CLEEN

1

Structured Record Retrieval

Every cleaning event, validation study, and analytical result stored in a searchable database. Query by equipment, product, date, operator, or status. Answers inspector questions in seconds.

Multi-Criteria Search Equipment History Date Range Filtering Status Queries

Record Sources

Cleaning Events
Validation Studies
Sample Results
Equipment Releases

Audit Portal

Structured Search
Equipment History
Trend Analysis

Output

Audit Response
Inspector Reports
2

21 CFR Part 11 Audit Trail

Complete electronic trail for every record. Who created it, who modified it, when, why, and the before/after values — all with electronic signatures. Meets ALCOA+ requirements.

Event Logging Before/After Capture E-Signatures ALCOA+ Compliance
3

Pre-Built Inspector Reports

One-click generation: cleaning summary per equipment, trend analysis, OOS with CAPAs, equipment status, worst-case matrices. Formatted to match inspector expectations.

Equipment Summary Trend Compilation OOS-CAPA Linkage Regulatory Formatting
4

Real-Time Equipment Status

Live dashboard: clean, dirty, in-process, on-hold, or released — for every piece of equipment across all sites.

Real-Time Status Multi-Site Aggregation Hold Time Monitoring Alerting
5

Deviation & CAPA Linkage

Complete chain in one view: OOS → deviation → CAPA → re-cleaning → verification → closure. No broken links.

OOS Detection Deviation Linking CAPA Tracking Closure Verification

The Solution

How Leucine Solves This

Purpose-built audit readiness for cleaning validation — addressing both documentation gaps and operational inefficiency.

CLEEN Audit Portal

Structured Retrieval with Inspector Reports

Every cleaning record in a searchable database. Pre-built reports generated in one click in formats inspectors expect.

  • Multi-criteria search across all cleaning records
  • One-click inspector-ready reports
  • Real-time equipment status across all sites
LeucineOS

21 CFR Part 11 Audit Trails & Data Integrity

Electronic signatures, audit trails with before/after values, role-based access, and record retention. Every action logged and attributable — meeting ALCOA+ requirements.

  • 21 CFR Part 11 — e-signatures, audit trails, access controls
  • ALCOA+ data integrity by design
  • Consistent audit trail standards across all facilities
FDA Tracker

Audit Intelligence from Enforcement Trends

Monitor cleaning validation 483s and warning letters across the industry. Know what inspectors are citing before they arrive at your facility.

  • Real-time monitoring of documentation-related 483s
  • Trend analysis of evolving data integrity expectations
  • Investigator profiling for documentation focus areas

Before & After

The Shift

Dimension
Paper & Spreadsheets
CLEEN Audit Portal
Record retrieval
Hours searching binders, shared drives, and LIMS
Seconds — query by equipment, product, date, or status
Audit trail
No electronic trail — no version control or signatures
Full 21 CFR Part 11 with e-signatures and before/after values
Inspector reports
Days to compile data from multiple sources
One-click pre-formatted reports
Equipment status
Paper whiteboards — hours or days behind
Real-time dashboard across all sites
Deviation chain
OOS in LIMS, deviation in QMS, re-cleaning on paper
Complete OOS-to-closure chain in one view
Multi-site
Each site has its own documentation approach
Uniform standards and audit readiness across all facilities

Results

Measurable Impact

Real results from manufacturers using the CLEEN Audit Portal.

80%
Cleaning Validation Cycles
Faster — Zydus reduced cleaning validation cycle times with CLEEN
100%
Calculation Errors
Elimination of manual calculation errors across all facilities
7+
Facilities
Zydus facilities with CLEEN deployed for cleaning validation

Next Step

Get Started

Stop failing audits because of disorganised documentation. CLEEN's Audit Portal gives you instant access to every cleaning record, compliant audit trails, and pre-built inspector reports.

Get Started
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